Acute renal failure (ARF), classically defined as an abrupt decrease in kidney function that
leads to accumulation of nitrogenous wastes such as blood urea nitrogen and creatinine, is …

Background: N-acetylcysteine, sodium bicarbonate, statins, and ascorbic acid have been
studied for reducing contrast-induced nephropathy (CIN). Purpose: To evaluate the …

Rationale: Measured at intensive care unit admission (ICU), the predictive value of
neutrophil gelatinase-associated lipocalin (NGAL) for severe acute kidney injury (AKI) is …

Renal ischemia-reperfusion (IR) contributes to the development of ischemic acute renal
failure (ARF). Multi-factorial processes are involved in the development and progression of …

PURPOSE: We sought to examine whether statin therapy before percutaneous coronary
intervention results in reduction in contrast-induced nephropathy (CIN). Intravascular …

BACKGROUND: Contrast media cause oxidative stress, which has been suggested as one
possible mechanism responsible for contrast-induced nephropathy. Statins appear to have …

Long-term effects of acute ischemia and reperfusion injury. Ischemia reperfusion (I/R) injury
plays a major role in delayed graft function and long-term changes after kidney …

Acute kidney injury (AKI) is a major renal disease associated with high mortality rate and
increasing prevalence. Decades of research have suggested numerous chemical and …

Background—Limited data suggest that HMG-CoA reductase inhibitors (statins) reduce rates
of kidney function loss. We performed this analysis to determine whether pravastatin …

Klotho is a single-pass transmembrane protein that is highly expressed in the kidney and is
known to act as a coreceptor for fibroblast growth factor 23. The extracellular domain can be …