Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

Ischemic heart disease (IHD) remains the leading cause of death and disability worldwide.
For patients presenting with an acute myocardial infarction, the most effective treatment for …

Under conditions of mitochondrial calcium overload, especially when accompanied by
oxidative stress, elevated phosphate concentrations and adenine nucleotide depletion, a …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Mitochondrial permeability transition, as the consequence of opening of a mitochondrial
permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse …

Obesity is well characterized as a systemic inflammatory condition, and is also associated
with cognitive disruption, suggesting a link between the two. We assessed whether …

1112 ELROD JW et al. red-sensitive mechanism (now known to be the mitochondrial
calcium uniporter (MCU), the genetic identity of which was recently discovered14–16) and …

Mitochondrial permeability transition is a phenomenon in which the mitochondrial
permeability transition pore (PTP) abruptly opens, resulting in mitochondrial membrane …

Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. It is
accompanied by other related polyphenols, including magnolol, with which it shares certain …

Mitochondria possess a Ca 2+ transport system composed of separate Ca 2+ influx and
efflux pathways. Intramitochondrial Ca 2+ concentrations regulate oxidative …