Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules

ZX He, YP Gong, X Zhang, LY Ma, W Zhao - European journal of medicinal …, 2021 - Elsevier
Identification of potent anticancer agents with high selectivity and low toxicity remains on the
way to human health. Pyridazine featuring advantageous physicochemical properties and …

Recent developments in the synthesis of hybrid heterocycles, a promising approach to develop multi-target antibacterial agents

KU Sadek, RA Mekheimer, M Abd-Elmonem… - Journal of Molecular …, 2023 - Elsevier
Hybrid molecules have become a well-established and powerful biologically relevant
heterocycles. They constitute a core structure due to their widespread use in pharmaceutical …

Synthesis of steroidal dihydropyrazole derivatives using green ZnO NPs and evaluation of their anticancer and antioxidant activity

A Ansari, A Ali, N Khan, MS Umar, M Owais - Steroids, 2022 - Elsevier
Abstract Zinc oxide nanoparticles (ZnO NPs) were synthesized by a green method using
Azadirachta indica leaf extract. The structure of the prepared ZnO (NPs) were characterized …

Synthesis of novel tritopic hydrazone ligands: spectroscopy, biological activity, DFT, and molecular docking studies

SA Rupa, MR Moni, MAM Patwary, MM Mahmud… - Molecules, 2022 - mdpi.com
Polytopic organic ligands with hydrazone moiety are at the forefront of new drug research
among many others due to their unique and versatile functionality and ease of strategic …

Determination of Chemical Composition, In Vitro and In Silico Evaluation of Essential Oil from Leaves of Apium graveolens Grown in Saudi Arabia

AI Foudah, MH Alqarni, A Alam, MA Salkini, P Alam… - Molecules, 2021 - mdpi.com
The aim of this study was to explore the composition and evaluate the in silico and in vitro
antioxidants and antimicrobial and anti-inflammatory effects of Apium graveolens var. dulce …

Synthesis and biological evaluation of novel benzo [a] pyridazino [3, 4-c] phenazine derivatives

G Le-Nhat-Thuy, TAD Thi, QGN Thi, PH Thi… - Bioorganic & Medicinal …, 2021 - Elsevier
A convenient microwave-assisted one-pot four-component synthetic approach was
developed en route to novel functionalized benzo [a] pyridazino [3, 4-c] phenazine …

Conventional and microwave irradiated synthesis, biological activity evaluation and molecular docking studies of highly substituted piperazine-azole hybrids

A Mermer, S Demirci, SB Ozdemir, A Demirbas… - Chinese Chemical …, 2017 - Elsevier
Abstract Azole derivatives (3, 6) obtained starting from 1-(2-methoxyphenyl) piperazine were
converted to the corresponding Mannich bases containing β-lactame or flouroquinolone …

Novel azole-functionalited flouroquinolone hybrids: Design, conventional and microwave irradiated synthesis, evaluation as antibacterial and antioxidant agents

M Mentese, N Demirbas, A Mermer… - Letters in Drug …, 2018 - ingentaconnect.com
Background: The synthesis of new hybrid molecules consisting of several heterocyclic
pharmacophores namely fluoroquinolone, 1, 2, 4-triazole, 1, 3, 4-oxadiazole and piperazine …

Itaconic acid hybrids as potential anticancer agents

I Perković, M Beus, D Schols, L Persoons, B Zorc - Molecular diversity, 2022 - Springer
In this paper, we report the synthesis of novel hybrids 2–14 based on itaconic acid and
fluoroaniline, pyridine, indole and quinoline scaffolds. Itaconic acid is a naturally occurring …

Catalytic and biological valorization of a supramolecular mononuclear copper complex based 4‐aminopyridine

N Hfidhi, I Bkhairia, D Atoui, J Boonmak… - Applied …, 2019 - Wiley Online Library
Hydrothermal reaction of copper bromide with 4‐aminopyridine in DMF solution yields a
new mononuclear copper complex [Cu (C5H6N2) 4] 2Br. 2 (C3H7NO) abbreviated Cu‐4AP …