The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …

Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …

Aims Fibrosis is associated with all forms of adult cardiac diseases including myocardial
infarction (MI). In response to MI, the heart undergoes ventricular remodelling that leads to …

An increasing number of studies suggest that the renal proximal tubule is a site of injury in
diabetic nephropathy (DN), and progressive renal tubulointerstitial fibrosis is an important …

Abstract Purpose of Review Organ fibrosis is a lethal component of scleroderma. The
hallmark of scleroderma fibrosis is extensive extracellular matrix (ECM) deposition by …

Fibrosis results from defective wound healing processes often seen after chronic injury
and/or inflammation in a range of organs. Progressive fibrotic events may lead to permanent …

Pathological remodeling of the extracellular matrix (ECM) by activated myofibroblasts is a
hallmark of fibrotic diseases and desmoplastic tumors. Activation of myofibroblasts occurs in …