Recent advances in the synthesis of indolizines and their π-expanded analogues

B Sadowski, J Klajn, DT Gryko - Organic & Biomolecular Chemistry, 2016 - pubs.rsc.org
Indolizine (pyrrolo [1, 2-a] pyridine) is one of the five isomers of indole and it serves as a
precursor for widespread indolizidine alkaloids. The straightforward synthesis of indolizines …

APOBEC enzymes as targets for virus and cancer therapy

ME Olson, RS Harris, DA Harki - Cell chemical biology, 2018 - cell.com
Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …

The APOBEC3 family of retroelement restriction factors

EW Refsland, RS Harris - Intrinsic immunity, 2013 - Springer
The ability to regulate and even target mutagenesis is an extremely valuable cellular asset.
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …

Development of benzimidazole derivatives to inhibit HIV-1 replication through protecting APOBEC3G protein

T Pan, X He, B Chen, H Chen, G Geng, H Luo… - European journal of …, 2015 - Elsevier
Abstract Human APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-
like 3G, A3G) is a potent restriction factor against human immunodeficiency virus type 1 (HIV …

Synthesis of Indolizines via Tf2O-Mediated Cascade Reaction of Pyridyl-enaminones with Thiophenols/Thioalcohols

C Zhang, W Wang, X Zhu, L Chen, H Luo, M Guo… - Organic …, 2023 - ACS Publications
A cost-effective, highly regioselective and metal-free version for the synthesis of indolizine
derivatives by means of Tf2O-mediated cascade reaction of pyridyl-enaminones and …

Synthesis of indolizines from pyridinium salts and ethyl bromodifluoroacetate

X Hou, S Zhou, Y Li, M Guo, W Zhao, X Tang… - Organic …, 2020 - ACS Publications
Here we present a novel annulation of pyridinium salts with BrCF2CO2Et to access the
indolizine derivatives with high efficiency. The α substitution of pyridine plays a key role in …

Inhibitory activities of indolizine derivatives: a patent review

KM Dawood, AA Abbas - Expert Opinion on Therapeutic Patents, 2020 - Taylor & Francis
Introduction Indolizines are structural isomers with indoles. Although several indole-based
commercial drugs are available in the market, none of the indolizine-based drugs are …

Enantioselective synthesis of 3-allylindolizines via sequential Rh-catalyzed asymmetric allylation and tschitschibabin reaction

K Li, C Li - Organic Letters, 2020 - ACS Publications
The first highly regio-and enantioselective synthesis of 3-allylindolizines has been
developed by the sequential Rh-catalyzed asymmetric allylation and Tschitschibabin …

Electro-Oxidative sp3 C–H Bond Functionalization and Annulation Cascade: Synthesis of Novel Heterocyclic Substituted Indolizines

BK Malviya, AK Jassal, M Karnatak… - The Journal of …, 2022 - ACS Publications
Indolizine derivatives are prevalent in many synthetic intermediates, pharmaceuticals, and
organic materials. Herein, we report a novel electro-oxidative cascade cyclization reaction …

Iron-catalyzed aerobic oxidation and annulation reaction of pyridine and α-substituted allenoate toward functionalized indolizine

T Jin, Z Tang, J Hu, H Yuan, Y Chen, C Li, X Jia… - Organic letters, 2018 - ACS Publications
Iron-Catalyzed Aerobic Oxidation and Annulation Reaction of Pyridine and α-Substituted Allenoate
toward Functionalized Indolizine | Organic Letters ACS ACS Publications C&EN CAS Find my …