Neuronal electrochemical signals involve the flux of sodium ions through voltage-gated
sodium channels (Na V) located in the neurolemma. Of the nine sodium channel subtypes …

Epidemiological studies reveal that symptoms of TMD occur in 60-70% of adults. The
inflammatory damage caused by TMD can easily lead to defects in the articular disc …

Nociceptive axons undergo remodeling as they innervate their targets during development
and in response to environmental insults and pathological conditions. How is nociceptive …

The sigma-1 receptor (Sig-1R) has emerged as a significant target in the realm of pain
management and has been the subject of extensive research. Nonetheless, its specific …

Background Decades following the introduction of vincristine as treatment for
haematological malignancies, vincristine-induced peripheral neuropathy (VIPN) remains a …

Rare genetic variants, characterized by their low frequency in a population, have emerged
as essential components in the study of complex disease genetics. The biology of rare …

This chapter reviews the neuroanatomy of the nociceptive system and its functional
organization. We describe three main compartments of the nervous system that underlie …

We aimed to investigate the genetic associations of neuropathic pain in a deeply
phenotyped cohort. Participants with neuropathic pain were cases and compared with those …

Infections with defined Herpesviruses, such as Pseudorabies virus (PRV) and Varicella
zoster virus (VZV) can cause neuropathic itch, referred to as “mad itch” in multiple species …