Autoimmune heparin‐induced thrombocytopenia (aHIT) indicates the presence in patients of
anti‐platelet factor 4 (PF4)–polyanion antibodies that are able to activate platelets strongly …

Background Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse
drug reaction that can lead to devastating thromboembolic complications, including …

This chapter about the recognition, treatment, and prevention of heparin-induced
thrombocytopenia (HIT) is part of the Antithrombotic and Thrombolytic Therapy: American …

Direct oral anticoagulants (DOACs) are attractive options for treatment of heparin-induced
thrombocytopenia (HIT). We report our continuing experience in Hamilton, ON, Canada …

The Handbook of Venoms and Toxins of Reptiles offers" one-stop shopping" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …

Many drugs have been implicated in drug-induced immune thrombocytopenia (DITP).
Patients with DITP develop a drop in platelet count 5 to 10 days after drug administration …

Heparin was discovered 90 years ago, 1 and within 2 decades it was being widely used as
an anticoagulant. 2 The numerous advantages of heparin lend to its broad use including its …

This review discusses the pharmacology and clinical applications of hirudin, a bivalent direct
thrombin inhibitor (DTI). Besides the current major indication for hirudin–anticoagulation of …

Heparin-induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by platelet-
activating IgG antibodies that recognize platelet factor 4 (PF4)/polyanion complexes. Platelet …

Several therapeutic agents can cause thrombocytopenia by either immune-mediated or non-
immune-mediated mechanisms. Non-immune-mediated thrombocytopenia is due to direct …