It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette
(ABC) transporter, can transport phospholipids such as phosphatidylcholine,− ethanolamine …

Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …

Glycinergic synapses play a central role in motor control and pain processing in the central
nervous system. Glycine receptors (GlyRs) are key players in mediating fast inhibitory …

Type A γ-aminobutyric acid receptors (GABAARs) are inhibitory pentameric ligand-gated ion
channels in the brain. Many anesthetics and neurosteroids act through binding to the …

The last five years have witnessed major developments in the understanding of the allosteric
phenomenon, broadly defined as coupling between remote molecular sites. Such advances …

The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in
electrochemical signal transduction across evolution, including historic model systems for …

Diminished inhibitory neurotransmission in the superficial dorsal horn of the spinal cord is
thought to contribute to chronic pain. In inflammatory pain, reductions in synaptic inhibition …

The α7 nicotinic acetylcholine receptor (α7nAChR) mediates signaling in the central nervous
system and cholinergic anti-inflammatory pathways. Ivermectin is a positive allosteric …

Cannabinoids exert therapeutic effects on several diseases such as chronic pain and startle
disease by targeting glycine receptors (GlyRs). Our previous studies have shown that …

Background Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical
transmission of nerve signals in the central and peripheral nervous system. On the functional …