Natural killer cell therapy targeting cancer stem cells: old wine in a new bottle
F Guo, Y Zhang, L Bai, J Cui - Cancer Letters, 2023 - Elsevier
A small proportion of cancer cells that have stem cell-like properties are known as cancer
stem cells (CSCs). They can be used to identify malignant tumor phenotypes and patients …
stem cells (CSCs). They can be used to identify malignant tumor phenotypes and patients …
Natural killer cells: diverse functions in tumor immunity and defects in pre-neoplastic and neoplastic stages of tumorigenesis
Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …
Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells
Glioblastoma multiforme (GBM), the most aggressive brain cancer, recurs because
glioblastoma stem cells (GSCs) are resistant to all standard therapies. We showed that …
glioblastoma stem cells (GSCs) are resistant to all standard therapies. We showed that …
[HTML][HTML] Development of humanized mouse and rat models with full-thickness human skin and autologous immune cells
The human skin is a significant barrier for protection against pathogen transmission. Rodent
models used to investigate human-specific pathogens that target the skin are generated by …
models used to investigate human-specific pathogens that target the skin are generated by …
Oncolytic viruses and immunity
S Chaurasiya, NG Chen, Y Fong - Current opinion in immunology, 2018 - Elsevier
Highlights•Oncolytic viruses (OVs) elicit innate and adaptive immune responses against
tumors.•Although the immune system can react against OVs, a functional immune system is …
tumors.•Although the immune system can react against OVs, a functional immune system is …
NK cells shape pancreatic and oral tumor microenvironments; role in inhibition of tumor growth and metastasis
We have recently shown that natural killer (NK) cells select and differentiate cancer stem
cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) …
cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) …
Probiotic-treated super-charged NK cells efficiently clear poorly differentiated pancreatic tumors in Hu-BLT mice
Background and Aims: We have previously demonstrated that the stage of differentiation of
tumors has profound effect on the function of NK cells, and that stem-like/poorly …
tumors has profound effect on the function of NK cells, and that stem-like/poorly …
Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and …
Therapeutic role of NK cells in solid tumors was challenged previously even though their
role in hematological malignancies has clearly been established. Furthermore, functions …
role in hematological malignancies has clearly been established. Furthermore, functions …
Natural killer cells target and differentiate cancer stem-like cells/undifferentiated tumors: strategies to optimize their growth and expansion for effective cancer …
Highlights•NK cells are effectors of selection and differentiation of CSCs/undifferentiated
tumors.•Induction of split anergy in NK cells is a mechanism for differentiation of tumor …
tumors.•Induction of split anergy in NK cells is a mechanism for differentiation of tumor …
[HTML][HTML] Harnessing natural killer cells for the treatment of ovarian cancer
JS Hoogstad-van Evert, R Bekkers, N Ottevanger… - Gynecologic …, 2020 - Elsevier
Introduction Adoptive cellular immunotherapy could be an interesting new treatment option
for ovarian carcinoma (OC), as research has demonstrated that OC is an immunogenic …
for ovarian carcinoma (OC), as research has demonstrated that OC is an immunogenic …