Emerging role of carbonic anhydrase inhibitors
CT Supuran - Clinical Science, 2021 - portlandpress.com
Inhibition of carbonic anhydrase (CA, EC 4.2. 1.1) was clinically exploited for decades, as
most modern diuretics were obtained considering as lead molecule acetazolamide, the …
most modern diuretics were obtained considering as lead molecule acetazolamide, the …
A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation
CT Supuran - Bioorganic & Medicinal Chemistry Letters, 2023 - Elsevier
Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …
are presented, with an emphasis on the deciphering of the activation mechanism, the …
Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology
During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …
been the primary model organisms used for the study of various biological phenomena …
[HTML][HTML] Carbonic anhydrase to boost CO2 sequestration: Improving carbon capture utilization and storage (CCUS)
A de Oliveira Maciel, P Christakopoulos, U Rova… - Chemosphere, 2022 - Elsevier
Abstract CO 2 Capture Utilization and Storage (CCUS) is a fundamental strategy to mitigate
climate change, and carbon sequestration, through absorption, can be one of the solutions …
climate change, and carbon sequestration, through absorption, can be one of the solutions …
Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
An overview on the recently discovered iota-carbonic anhydrases
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) have been studied for decades and have
been classified as a superfamily of enzymes which includes, up to date, eight gene families …
been classified as a superfamily of enzymes which includes, up to date, eight gene families …
A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors
Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established
anticancer drug targets and their selective inhibition is highly desired for the proper …
anticancer drug targets and their selective inhibition is highly desired for the proper …
Selected strategies to fight pathogenic bacteria
A Plotniece, A Sobolev, CT Supuran… - Journal of enzyme …, 2023 - Taylor & Francis
Natural products and analogues are a source of antibacterial drug discovery. Considering
drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes …
drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes …
Structure–Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae
Neisseria gonorrhoeae is an urgent threat to public health in the United States and around
the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are …
the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are …
Sulfonamide inhibitors of human carbonic anhydrases designed through a three-tails approach: improving ligand/isoform matching and selectivity of action
The “tail approach” has become a milestone in human carbonic anhydrase inhibitor (hCAI)
design for various therapeutics, including antiglaucoma agents. Besides the classical …
design for various therapeutics, including antiglaucoma agents. Besides the classical …