A comprehensive survey of regulatory network inference methods using single cell RNA sequencing data

H Nguyen, D Tran, B Tran, B Pehlivan… - Briefings in …, 2021 - academic.oup.com
Gene regulatory network is a complicated set of interactions between genetic materials,
which dictates how cells develop in living organisms and react to their surrounding …

Redefining fundamental concepts of transcription initiation in bacteria

C Mejía-Almonte, SJW Busby, JT Wade… - Nature Reviews …, 2020 - nature.com
Despite enormous progress in understanding the fundamentals of bacterial gene regulation,
our knowledge remains limited when compared with the number of bacterial genomes and …

Disentangling direct from indirect relationships in association networks

N Xiao, A Zhou, ML Kempher… - Proceedings of the …, 2022 - National Acad Sciences
Networks are vital tools for understanding and modeling interactions in complex systems in
science and engineering, and direct and indirect interactions are pervasive in all types of …

[HTML][HTML] Genomic and functional analyses of fungal and bacterial consortia that enable lignocellulose breakdown in goat gut microbiomes

X Peng, SE Wilken, TS Lankiewicz, SP Gilmore… - Nature …, 2021 - nature.com
The herbivore digestive tract is home to a complex community of anaerobic microbes that
work together to break down lignocellulose. These microbiota are an untapped resource of …

[HTML][HTML] Systematic exploration of Escherichia coli phage–host interactions with the BASEL phage collection

E Maffei, A Shaidullina, M Burkolter, Y Heyer… - PLoS …, 2021 - journals.plos.org
Bacteriophages, the viruses infecting bacteria, hold great potential for the treatment of
multidrug-resistant bacterial infections and other applications due to their unparalleled …

RegulonDB 11.0: Comprehensive high-throughput datasets on transcriptional regulation in Escherichia coli K-12

VH Tierrafría, C Rioualen, H Salgado… - Microbial …, 2022 - microbiologyresearch.org
Genomics has set the basis for a variety of methodologies that produce high-throughput
datasets identifying the different players that define gene regulation, particularly regulation …

[HTML][HTML] Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure

J Zrimec, CS Börlin, F Buric, AS Muhammad… - Nature …, 2020 - nature.com
Understanding the genetic regulatory code governing gene expression is an important
challenge in molecular biology. However, how individual coding and non-coding regions of …

RSAT 2022: regulatory sequence analysis tools

W Santana-Garcia, JA Castro-Mondragon… - Nucleic Acids …, 2022 - academic.oup.com
Abstract RSAT (Regulatory Sequence Analysis Tools) enables the detection and the
analysis of cis-regulatory elements in genomic sequences. This software suite performs (i) …

Prokaryotic single-cell RNA sequencing by in situ combinatorial indexing

SB Blattman, W Jiang, P Oikonomou, S Tavazoie - Nature microbiology, 2020 - nature.com
Despite longstanding appreciation of gene expression heterogeneity in isogenic bacterial
populations, affordable and scalable technologies for studying single bacterial cells have …

PRODORIC: state-of-the-art database of prokaryotic gene regulation

CA Dudek, D Jahn - Nucleic acids research, 2022 - academic.oup.com
PRODORIC is worldwide one of the largest collections of prokaryotic transcription factor
binding sites from multiple bacterial sources with corresponding interpretation and …