Role of the microbiome in gut-heart-kidney cross talk

G Glorieux, SK Nigam, R Vanholder… - Circulation …, 2023 - Am Heart Assoc
Homeostasis is a prerequisite for health. When homeostasis becomes disrupted, dysfunction
occurs. This is especially the case for the gut microbiota, which under normal conditions …

Consumption of fish in chronic kidney disease–A matter of depth

D Mafra, JA Kemp, VO Leal, L Cardozo… - Molecular Nutrition & …, 2023 - Wiley Online Library
Fish is an excellent source of ω‐3 polyunsaturated fatty acids (PUFAs), amino acids,
collagen, vitamins, and iodine and its intake is associated with health benefits, mainly …

[HTML][HTML] Furan fatty acid metabolite CMPF is associated with lower risk of type 2 diabetes, but not chronic kidney disease: a longitudinal population-based cohort study

Z Miao, FF Zeng, Y Tian, C Xiao, Y Yan, Z Jiang… - The American Journal of …, 2023 - Elsevier
Background Furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid
(CMPF) is a strong biomarker of fish and n-3 polyunsaturated fatty acid (PUFA) intake. The …

The Effect of Inulin‐Type Fructans on Plasma Trimethylamine N‐Oxide Levels in Peritoneal Dialysis Patients: A Randomized Crossover Trial

Q Xiong, L Li, Y Xiao, S He, J Zhao… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Trimethylamine N‐oxide (TMAO), an important proatherogenic uremic toxin, is
oxidized by hepatic‐flavin monooxygenases from gut microbiome‐generated trimethylamine …

A normative microbiome is not restored following kidney transplantation

H Craven, H Erlandsson, D McGuinness… - Clinical …, 2023 - portlandpress.com
Dialysis and kidney transplantation (Ktx) mitigate some of the physiological deficits in
chronic kidney disease (CKD), but it remains to be determined if these mitigate microbial …

The dietary source of trimethylamine N-oxide and clinical outcomes: an unexpected liaison

M Evans, L Dai, CM Avesani, K Kublickiene… - Clinical Kidney …, 2023 - academic.oup.com
The profile of gut microbiota can vary according to host genetic and dietary characteristics,
and be influenced by disease state and environmental stressors. The uremic dysbiosis …

Causal relationship between blood metabolites and risk of five infections: a Mendelian randomization study

Z Wei, Q Xiong, D Huang, Z Wu, Z Chen - BMC Infectious Diseases, 2023 - Springer
Objective Infectious diseases continue to pose a significant threat in the field of global public
health, and our understanding of their metabolic pathogenesis remains limited. However …

Mendelian randomization analysis reveals causal associations of serum metabolites with sepsis and 28-day mortality

G Jing, J Zuo, Z Liu, H Liu, M Cheng, M Yuan… - Scientific Reports, 2024 - nature.com
Metabolic disorder has been found to be an important factor in the pathogenesis and
progression of sepsis. However, the causation of such an association between serum …

Pathological mechanisms of kidney disease in ageing

T Yamamoto, Y Isaka - Nature Reviews Nephrology, 2024 - nature.com
The kidney is a metabolically active organ that requires energy to drive processes such as
tubular reabsorption and secretion, and shows a decline in function with advancing age …

Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke

Y Liu, J Qu, J Xu, A Gu, D Deng, X Jia… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke is by far the most common cerebrovascular disease and a major burden to
the global economy and public health. Trimethylamine-N-oxide (TMAO), a small molecule …