MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary
target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear …

Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …

Abstract Background Micro-RNAs (miRNAS) are non-coding, small RNAs that have
essential roles in different biological processes through silencing genes, they consist of 18 …

New discoveries in RNA biology underscore a need for chemical tools to clarify their roles in
pathophysiological mechanisms. In certain cancers, synthesis of the let-7 microRNA tumor …

Although cancer stem-like cells (CSC) are thought to be the most tumorigenic, metastatic,
and therapy-resistant cell subpopulation within human tumors, current therapies target bulk …

MicroRNAs (miRNAs) regulate gene expression by targeting protein-coding transcripts that
are involved in various cellular processes. Thus, miRNA biogenesis has been recognized as …

The protein Lin28 and microRNA let-7 play critical roles in mammalian development and
human disease. Lin28 inhibits let-7 biogenesis through direct interaction with let-7 …

The recombination signal binding protein for immunoglobulin kappa J region (RBPJ) has a
dual effect on Kaposi's sarcoma-associated herpesvirus (KSHV) replication. RBPJ …

In vitro selection was used to obtain l-RNA aptamers that bind the distal stem-loop of various
precursor microRNAs (pre-miRs). These l-aptamers, termed “aptamiRs”, bind their …

The let-7 family of miRNAs has been shown to be crucial in many aspects of biology, from
the regulation of developmental timing to cancer. The available methods to regulate this …