Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …

Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

In response to varying stress signals, the p53 tumor suppressor is able to promote repair,
survival, or elimination of damaged cells–processes that have great relevance to organismal …

Growth and differentiation factor 11 (GDF11) is a transforming growth factor β superfamily
member with a controversial role in aging processes. We have developed a highly specific …

Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular
level, ageing entails decreased replicative capacity and dysregulation of cellular processes …

Osteoporosis is an age-related disease that affects millions of people. Growth differentiation
factor 11 (GDF11) is a secreted member of the transforming growth factor beta (TGF-β) …

Aging is characterized by the progressive dysfunction of most tissues and organs, which has
been linked to the regenerative decline of their resident stem cells over time. Skeletal …

It has long been known that aging, at both the cellular and organismal levels, contributes to
the development and progression of the pathology of many chronic diseases. However …

Growth and differentiation factor (GDF) 11 is a member of the transforming growth factor β
superfamily recently identified as a potential therapeutic for age‐related cardiac and skeletal …

Background Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar
members of the transforming growth factor β (TGFβ) family. While GDF8 has been …