Role of alcohol oxidative metabolism in its cardiovascular and autonomic effects

MM El-Mas, AA Abdel-Rahman - … to Human Health and Precision Medicine, 2019 - Springer
Several review articles have been published on the neurobehavioral actions of
acetaldehyde and other ethanol metabolites as well as in major alcohol-related disorders …

Melatonin for neonatal encephalopathy: from bench to bedside

R Pang, A Advic-Belltheus, C Meehan… - International Journal of …, 2021 - mdpi.com
Neonatal encephalopathy is a leading cause of morbidity and mortality worldwide. Although
therapeutic hypothermia (HT) is now standard practice in most neonatal intensive care units …

The effect of chronic activation of the novel endocannabinoid receptor GPR18 on myocardial function and blood pressure in conscious rats

AI Matouk, A Taye, MA El-Moselhy… - Journal of …, 2017 - journals.lww.com
Although acute activation of the novel endocannabinoid receptor GPR18 causes
hypotension, there are no reports on GPR18 expression in the heart or its chronic …

Dysregulated ACE/Ang II/Ang1-7 signaling provokes cardiovascular and inflammatory sequelae of endotoxemia in weaning preeclamptic rats

SA Abuiessa, MM Helmy, HM El-Gowelli… - European Journal of …, 2022 - Elsevier
Weaning preeclamptic (PE) rats exhibit exaggerated endotoxic signs of hypotension and
cardiac autonomic neuropathy. Considering the role of renin-angiotensin system (RAS) in …

Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: a role for angiotensin type 1 receptor

A Yogi, GE Callera, AS Mecawi, ME Batalhão… - Toxicology and Applied …, 2012 - Elsevier
Ethanol intake is associated with increase in blood pressure, through unknown
mechanisms. We hypothesized that acute ethanol intake enhances vascular oxidative stress …

Acute ethanol intake induces mitogen-activated protein kinase activation, platelet-derived growth factor receptor phosphorylation, and oxidative stress in resistance …

NA Gonzaga, GE Callera, A Yogi, AS Mecawi… - Journal of physiology …, 2014 - Springer
In the present study, we investigated the role of angiotensin type I (AT 1) receptor in reactive
oxygen species (ROS) generation and mitogen-activated protein kinases (MAPK) activation …

Facilitation of myocardial PI3K/Akt/nNOS signaling contributes to ethanol‐evoked hypotension in female rats

MM El‐Mas, M Fan… - Alcoholism: Clinical and …, 2009 - Wiley Online Library
Background: The mechanism by which ethanol reduces cardiac output (CO) and blood
pressure (BP) in female rats remains unclear. We tested the hypothesis that enhancement of …

Pioglitazone abrogates cyclosporine-evoked hypertension via rectifying abnormalities in vascular endothelial function

MM El-Mas, HM El-Gowelli, KS Abd-Elrahman… - Biochemical …, 2011 - Elsevier
In addition to insulin sensitization, the thiazolidenedione drug pioglitazone exhibits
favorable circulatory effects. Here, we hypothesized that pioglitazone protects against the …

Gestational NSAIDs distinctly reprogram cardiac injury in preeclamptic rats: Roles of cyclooxygenase, apoptotic and autophagic trails

MA Ali, SA Abdelhady, DM Yacout, LS Kandil… - Life Sciences, 2022 - Elsevier
Aims Considering the role of cyclooxygenases (COX) in placental programming induced by
preeclampsia (PE), we investigated whether gestational exposure to nonsteroidal …

Endothelin ETA receptor/lipid peroxides/COX‐2/TGF‐β1 signalling underlies aggravated nephrotoxicity caused by cyclosporine plus indomethacin in rats

MW Helmy, HM El‐Gowelli, RM Ali… - British Journal of …, 2015 - Wiley Online Library
Background and Purpose Cyclosporine (CSA) and non‐steroidal anti‐inflammatory drugs
(NSAIDs) are co‐prescribed for some arthritic conditions. We tested the hypothesis that this …