The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type
II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in …

Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as
saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and …

Metal-based photosensitizers are of interest as their absorption and chemical binding
properties can be modified via the use of different ligands. Ru 2+ based photosensitizers are …

Iron is essential for cell growth and is imported into cells in part through the action of
transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and …

In persistent infections that are accompanied by chronic immune activation, such as human
immunodeficiency virus, hepatitis C virus, and malaria, there is an increased frequency of a …

Osteosarcoma is a kind of primary bone malignant tumors. Its cure rate has been stagnant in
the past decade years. Curcin C belongs to type I ribosome inactivating proteins, extracted …

Transferrin (Tf), widely known for its role as an iron-binding protein, exemplifies multitasking
in biological processes. The role of Tf in iron metabolism involves both the uptake of iron …

Despite emerging targeted and immunotherapy treatments, no monoclonal antibodies or
antibody-drug conjugates (ADCs) directly targeting tumor cells are currently approved for …

Editorial Daniels-Wells & Penichet which ultimately interfere with iron uptake leading to
lethal iron starvation [2]. Additionally, both neutralizing and non-neutralizing antibodies can …

Abstract The transferrin receptor 1 (TfR1) is an attractive target for Ab-mediated cancer
therapy. We previously developed a mouse/human chimeric IgG3 Ab (ch128. 1) targeting …