Frailty, a consequence of the interaction of the aging process and certain chronic diseases,
compromises functional outcomes in the elderly and substantially increases their risk for …

Increase in life-span is commonly related with age-related diseases and with gradual loss of
genomic, proteomic and metabolic integrity. Nrf2 (Nuclear factor-erythroid 2-p45 derived …

Aging is associated with increased oxidative stress in vascular endothelial and smooth
muscle cells, which contribute to the development of a wide range of diseases affecting the …

Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and
immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is …

Purpose: One of the cause of adaptations due to exercise training is increased capillary
density or angiogenesis. increased blood flow to hippocampus tissue causes improvement …

Significance: Nuclear factor erythroid 2 (NFE2)-related factor 2 (NFE2L2, or NRF2) is a
transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays …

Geroscience, an emerging discipline at the intersection of aging and disease, seeks to
understand the relationship between the aging process and pathogenesis of age-related …

Oxidative stress and mitochondrial dysfunction are associated with the aging process.
However, the role of nuclear factor erythroid 2‐related factor 2 (Nrf2) in skeletal muscle …

Our previous studies support a key role for mitochondrial lipid hydroperoxides as important
contributors to denervation-related muscle atrophy, including muscle atrophy associated …

Sarcopenia remains one of the major pathological features of type 2 diabetes (T2D),
especially in older individuals. This condition describes gradual loss of muscle mass …