In β cells, stimulation by metabolic, hormonal, neuronal, and pharmacological factors is
coupled to secretion of insulin through different intracellular signaling pathways. Our …

Islets of Langerhans are multicellular microorgans located in the pancreas that play a central
role in whole-body energy homeostasis. Through secretion of insulin and other hormones …

Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic β cell
destruction induced by islet reactive T cells that have escaped central tolerance. Many …

Somatostatin is a paracrine modulator of insulin secretion and beta cell function with
pleotropic effects on glucose homeostasis. The mechanism of somatostatin-mediated …

Beta cells within the pancreatic islets of Langerhans respond to stimulation with coherent
oscillations of membrane potential and intracellular calcium concentration that presumably …

Many details of glucose-stimulated intracellular calcium changes in β cells during activation,
activity, and deactivation, as well as their concentration-dependence, remain to be analyzed …

Although mice are a very instrumental model in islet beta cell research, possible phenotypic
differences between strains and substrains are largely neglected in the scientific community …

NMDA receptors promote repolarization in pancreatic beta cells and thereby reduce glucose-
stimulated insulin secretion. Therefore, NMDA receptors are a potential therapeutic target for …

Cholinergic innervation in the pancreas controls both the release of digestive enzymes to
support the intestinal digestion and absorption, as well as insulin release to promote nutrient …

Electrical activity and oscillations of cytosolic Ca 2+ concentrations ([Ca 2+] i) that trigger
insulin release in response to glucose are key functions of pancreatic β cells. Although …