The role of inflammasomes as central inflammatory hubs in Mycobacterium tuberculosis infection
SJ Theobald, TA Müller, D Lange, K Keck… - Frontiers in …, 2024 - frontiersin.org
Mycobacterium tuberculosis (Mtb) infection represents a global health problem and is
characterized by formation of granuloma with a necrotic center and a systemic inflammatory …
characterized by formation of granuloma with a necrotic center and a systemic inflammatory …
Single-nucleotide variants in the AIM2–absent in melanoma 2 gene (rs1103577) associated with protection for tuberculosis
MBA Figueira, DS de Lima, AL Boechat… - Frontiers in …, 2021 - frontiersin.org
Tuberculosis (TB) remains a serious public health burden worldwide. TB is an infectious
disease caused by the Mycobacterium tuberculosis Complex. Innate immune response is …
disease caused by the Mycobacterium tuberculosis Complex. Innate immune response is …
Distinct gene expression signatures comparing latent tuberculosis infection with different routes of Bacillus Calmette-Guérin vaccination
RF Silver, M Xia, CE Storer, JR Jarvela… - Nature …, 2023 - nature.com
Tuberculosis remains an international health threat partly because of limited protection from
pulmonary tuberculosis provided by standard intradermal vaccination with Bacillus of …
pulmonary tuberculosis provided by standard intradermal vaccination with Bacillus of …
The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation
RAG Cambui, FP Fernandes, VNC Leal… - Journal of Cancer …, 2023 - Springer
Purpose TMEM176B was recently described as a negative modulator of Nlrp3
inflammasome activation in mice. In the mouse model, the inhibition of TMEM176B leads to …
inflammasome activation in mice. In the mouse model, the inhibition of TMEM176B leads to …
Comparative genetic association analysis of human genetic susceptibility to pulmonary and lymph node tuberculosis
M Bose, A Giri, M Varma-Basil - Genes, 2023 - mdpi.com
Background: Tuberculosis (TB) manifests itself primarily in the lungs as pulmonary disease
(PTB) and sometimes disseminates to other organs to cause extra-pulmonary TB, such as …
(PTB) and sometimes disseminates to other organs to cause extra-pulmonary TB, such as …
Mycobacterium tuberculosis-dependent monocyte expression quantitative trait loci, cytokine production, and TB pathogenesis
H Hong, KA Dill-McFarland, JD Simmons… - Frontiers in …, 2024 - frontiersin.org
Introduction The heterogeneity of outcomes after Mycobacterium tuberculosis (Mtb)
exposure is a conundrum associated with millennia of host-pathogen co-evolution. We …
exposure is a conundrum associated with millennia of host-pathogen co-evolution. We …
Impact of IL-1β on lung pathology caused by Mycobacterium abscessus infection and its association with IL-17 production
JH Ahn, DH Jung, DY Kim, TS Lee, YJ Kim, YJ Lee… - Microbes and …, 2024 - Elsevier
Mycobacterium abscessus (MAB), a non-tuberculous mycobacterium (NTM), causes chronic
pulmonary inflammation in humans. The NLRP3 inflammasome is a multi-protein complex …
pulmonary inflammation in humans. The NLRP3 inflammasome is a multi-protein complex …
A genetic variant in the TRAF1/C5 gene lead susceptibility to active pulmonary tuberculosis by decreased TNF-α levels
DS de Lima, CF de Brito, ARC Barbosa… - Microbial …, 2021 - Elsevier
Host genetics are important to consider in the role of resistance or susceptibility for
developing active pulmonary tuberculosis (TB). Several association studies have reported …
developing active pulmonary tuberculosis (TB). Several association studies have reported …
Cell death induced by NLRP3–palmitate axis impairs pulmonary damage tolerance and aggravates immunopathology during obesity‐tuberculosis comorbidity
SP Palma Albornoz, TFC Fraga‐Silva… - The Journal of …, 2023 - Wiley Online Library
A low‐grade and persistent inflammation, which is the hallmark of obesity, requires the
participation of NLRP3 and cell death. During Mycobacterium tuberculosis infection, NLRP3 …
participation of NLRP3 and cell death. During Mycobacterium tuberculosis infection, NLRP3 …
The association between CCR5, NLRC4, and AIM2 gene polymorphisms and susceptibility to tuberculosis in the Iraqi population.
B KHALEEL, HRS AL-ALWANI… - Biodiversitas: Journal of …, 2024 - search.ebscohost.com
Abstract Khaleel B, Al-Alwani HRS, Asmar A. 2024. The association between CCR5,
NLRC4, and AIM2 gene polymorphisms and susceptibility to tuberculosis in the Iraqi …
NLRC4, and AIM2 gene polymorphisms and susceptibility to tuberculosis in the Iraqi …