The γδ T cell lineage in humans remains much of an enigma due to the low number of
defined antigens, the non-canonical ways in which these cells respond to their environment …

Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial
pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the …

T lymphocytes expressing the T cell receptor (TCR)-γδ recognize unknown antigens on
tumor cells. Here we identify metabolites of the mevalonate pathway as the tumor ligands …

Human γδ T cells are considered to play a vital role in protective immunity through cytokine
secretion and cytotoxic activity. We report that cells expressing the Vγ2Vδ2+–T cell receptor …

The increasing evidence that γδ T cells have potent antitumor activity suggests their value in
immunotherapy, particularly in areas of unmet need such as metastatic carcinoma. To this …

Increasing immunological knowledge and advances in techniques lay the ground for more
efficient and broader application of immunotherapies. gamma delta (γδ) T-cells possess …

Epithelial and mucosal barriers are critical interfaces physically separating the body from the
outside environment and are the tissues most exposed to microorganisms and potential …

To examine the role of T cell receptor (TCR) in γδ T cells in adaptive immunity, a macaque
model was used to follow Vγ2Vδ2+ T cell responses to mycobacterial infections. These …

The potent anti-tumour activities of γδ T cells have prompted the development of protocols in
which γδ-agonists are administered to cancer patients. Encouraging results from small …

Vδ2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules
and mount both immediate effector functions and memory responses after microbial …