Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

The most critical risk factor for optic nerve damage in cases of primary open-angle glaucoma
(POAG) is an increased intraocular pressure (IOP) caused by a resistance to aqueous …

The cause of the elevated outflow resistance and consequent ocular hypertension
characteristic of glaucoma is unknown. To investigate possible causes for this flow …

Aniridia is a congenital and progressive panocular condition with poor visual prognosis that
is associated with brain, olfactory, and pancreatic abnormalities. Development of aniridia is …

Congenital aniridia is a panocular disorder that is typically characterized by iris hypoplasia
and aniridia-associated keratopathy (AAK). AAK results in the progressive loss of corneal …

Genome-encoded microRNAs (miRNAs) provide a post-transcriptional regulatory layer that
is important for pancreas development. However, how specific miRNAs are intertwined into …

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a
valuable model system to study the generation and mechanisms modulating conventional …

While all forms of glaucoma are characterized by a specific pattern of retinal ganglion cell
death, they are clinically divided into several distinct subclasses, including normal tension …

Lens induction is a classical developmental model allowing investigation of cell
specification, spatiotemporal control of gene expression, as well as how transcription factors …