Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Positron emission tomography (PET) is an important driver for present day healthcare.
Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview …

PET myocardial perfusion imaging (MPI) is increasingly being used for noninvasive
detection and evaluation of coronary artery disease. However, the widespread use of PET …

Absolute quantitation of myocardial blood flow (MBF) by PET is an established method of
analyzing coronary artery disease (CAD) but subject to the various shortcomings of …

With the development of positron emission tomography (PET) technology, a variety of PET
imaging agents labeled with radionuclide 18 F have been developed and widely used in the …

The mitochondrion's negatively charged membrane potential has been well documented to
drive the accumulation of membrane permeable delocalized lipophilic cations (DLC). DLC …

Radiolabeled lipophilic cationic compounds, such as 18F-labeled phosphonium salt,
accumulate in the mitochondria through a negative inner transmembrane potential. The …

Recently, we demonstrated the potential of a [18F]‐trimethylammonium BODIPY dye for
cardiac imaging. This is the first example of the use of the [18F]‐ammonium BODIPY dye for …

This chapter covers the literature published during 2013 relating to the above area, apart
from a few papers from 2012 in less accessible journals which came to light in Chemical …

INTRODUCTION: Established radiotracers for positron emission tomography (PET)
myocardial perfusion study are commonly labeled with short-lived radio-isotopes that limit …