Self-inflicted DNA strand breaks are canonically linked with cell death pathways and the
establishment of genetic diversity in immune and germline cells. Moreover, this form of DNA …

Cancer genomes frequently harbor structural chromosomal rearrangements that disrupt the
linear DNA sequence order and copy number. To date, diverse classes of structural variants …

Abnormal numerical and structural chromosome content is frequently found in human
cancer. To test the role of aneuploidy in tumor initiation and progression, we generated mice …

Detecting and targeting precancerous cells in noncancerous tissues is a major challenge for
cancer prevention. Massive stabilization of mutant p53 (mutp53) proteins is a cancer-specific …

The alternative non-homologous end-joining (NHEJ) pathway promotes DNA double-strand
break (DSB) repair in cells deficient for NHEJ or homologous recombination, suggesting that …

When cells progress to malignancy, they must overcome a final telomere-mediated
proliferative lifespan barrier called replicative crisis. Crisis is characterized by extensive …

Lineage switches in acute leukemia occur rarely, and the underlying mechanisms are poorly
understood. Herein, we report the case of an elderly patient with leukemia in which the …

Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of
which cannot be easily classified into simple (eg deletion, translocation) or complex (eg …

Genomic instability caused by chromosomal rearrangements has severe consequences for
organismal fitness and progression of cancerous cell lines. The triggers of destabilized …

Liposarcomas are a heterogeneous group of sarcomas, including well-differentiated and
dedifferentiated liposarcoma, myxoid/round cell liposarcoma, and pleomorphic liposarcoma …