Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-
forming proteins. The cleavage of gasdermins by specific proteases enables their pore …

Since the identification and characterization of gasdermin (GSDM) D as the main effector of
inflammatory regulated cell death (or pyroptosis), literature on the GSDM family of pore …

Although tuft cells were discovered over 60 years ago, their functions have long been
enigmatic, especially in human health. Nonetheless, tuft cells have recently emerged as key …

Dysregulated metabolism, cell death, and inflammation contribute to the development of
metabolic dysfunction-associated steatohepatitis (MASH). Pyroptosis, a recently identified …

A specialized population of mast cells residing within epithelial layers, currently known as
intraepithelial mast cells (IEMCs), was originally observed over a century ago, yet their …

The involvement of the Gasdermin (GSDM) protein family in cancer and other pathologies is
one of the hottest topics in biomedical research. There are six GSDMs in humans (GSDMA …

The programmed cell death machinery exhibits surprising flexibility, capable of crosstalk and
non-apoptotic roles. Much of this complexity arises from the diverse functions of caspase-8 …

Gasdermins (GSDMs) share a common functional domain structure and are best known for
their capacity to form membrane pores. These pores are hallmarks of a specific form of cell …

The epithelium is an integral component of mucosal barrier and host immunity. Following
helminth infection, the intestinal epithelial cells secrete" alarmin" cytokines, such as …

The intestine is characterized by an environment in which host requirements for nutrient and
water absorption are consequently paired with the requirements to establish tolerance to the …