In recent years, the field of neuroimaging dramatically moved forward by means of the
expeditious development of specific radioligands of novel targets. Among these targets, the …

Many neurological disorders are related to synaptic loss or pathologies. Before the boom of
positrons emission tomography (PET) imaging of synapses, synaptic quantification could …

How does the organization of neural information processing enable humans' sophisticated
cognition? Here we decompose functional interactions between brain regions into …

Background Synaptic loss is a prominent and early feature of many neurodegenerative
diseases. Objectives We tested the hypothesis that synaptic density is reduced in the …

There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical
models and human in vivo and post mortem studies. Understanding the consequences of …

Abstract Objective Dementia with Lewy bodies (DLB) is a common cause of dementia, but
atrophy is mild compared to Alzheimer's disease. We propose that DLB is associated …

Introduction-Several 11C-tracers have demonstrated high potential in early diagnostic PET
imaging applications of neurodegenerative diseases including Alzheimer's and Parkinson's …

Synaptic loss is an early feature of neurodegenerative disease models, and is often severe
in post mortem clinical studies, including frontotemporal dementia. Positron emission …

Abstract Rationale [11 C]-UCB-J is an emerging tool for the noninvasive measurement of
synaptic vesicle density in vivo. Here, we report human biodistribution and dosimetry …

18F-labelled radiotracers are in high demand and play an important role for diagnostic
imaging with positron emission tomography (PET). Challenges associated with the synthesis …