Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …

In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular
zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young …

Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to
injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem …

Tissues have a natural capacity to replace dying cells and to heal wounds. This ability
resides in resident stem cells, which self-renew, preserve, and repair their tissue during …

Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the
mammalian hippocampus. We used chronic in vivo imaging and followed genetically …

Metastasis-initiating cells with stem-like properties drive cancer lethality, yet their origins and
relationship to primary-tumor-initiating stem cells are not known. We show that L1CAM+ …

Skin architecture and function depend on diverse populations of epidermal cells and dermal
fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in …

INTRODUCTION Liquid-liquid phase separation of biopolymers has emerged as a driving
force for assembling membraneless biomolecular condensates. Despite substantial …

To establish and maintain organ structure and function, tissues need to balance stem cell
proliferation and differentiation rates and coordinate cell fate with position. By quantifying …

Somatic stem cells have been identified in multiple adult tissues. Whether self-renewal
occurs symmetrically or asymmetrically is key to understanding long-term stem cell …