Chronic pulmonary hypertension is a serious complication of a number of chronic lung and
heart diseases. In addition to vasoconstriction, its pathogenesis includes injury to the …

Delivery of oxygen to tissues is the primary function of the cardiovascular system. NO, a
gasotransmitter that signals predominantly through protein S-nitrosylation to form S …

Previously, we reported that red blood cells (RBCs) of rabbits and humans release ATP in
response to mechanical deformation and that this release of ATP requires the activity of the …

Chronic hypoxia induces pulmonary hypertension and right ventricular (RV) hypertrophy.
Nitric oxide (NO) has been proposed to modulate the pulmonary vascular response to …

High-resolution measurements of pulmonary perfusion reveal substantial spatial
heterogeneity that is fractally distributed. This observation led to the hypothesis that the …

Previously, it was reported that red blood cells (RBCs) are required to demonstrate
participation of nitric oxide (NO) in the regulation of rabbit pulmonary vascular resistance …

The trapping, processing, and delivery of nitric oxide (NO) bioactivity by red blood cells
(RBCs) have emerged as a conserved mechanism through which regional blood flow is …

Previously, we reported that in the isolated perfused rabbit lung, red blood cells (RBCs)
obtained from either rabbits or healthy humans were a required component of the perfusate …

Монография посвящена весьма актуальной научной и методической проблеме,
связанной с вопросами синергизма и устойчивости гомеостаза организма человека. В …

Background Nonselective nitric oxide synthase (NOS) inhibition has detrimental effects in
sepsis because of inhibition of the physiologically important endothelial NOS (eNOS). The …