Measuring biological age using omics data

J Rutledge, H Oh, T Wyss-Coray - Nature Reviews Genetics, 2022 - nature.com
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Aging hallmarks and the role of oxidative stress

E Maldonado, S Morales-Pison, F Urbina, A Solari - Antioxidants, 2023 - mdpi.com
Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Advances and utility of the human plasma proteome

EW Deutsch, GS Omenn, Z Sun, M Maes… - Journal of proteome …, 2021 - ACS Publications
The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …

Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations

MA Argentieri, S Xiao, D Bennett, L Winchester… - Nature medicine, 2024 - nature.com
Circulating plasma proteins play key roles in human health and can potentially be used to
measure biological age, allowing risk prediction for age-related diseases, multimorbidity and …

Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain

MT Buckley, ED Sun, BM George, L Liu, N Schaum… - Nature Aging, 2023 - nature.com
The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …

Human age reversal: Fact or fiction?

AA Johnson, BW English, MN Shokhirev… - Aging …, 2022 - Wiley Online Library
Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …

Thermal facial image analyses reveal quantitative hallmarks of aging and metabolic diseases

Z Yu, Y Zhou, K Mao, B Pang, K Wang, T Jin, H Zheng… - Cell Metabolism, 2024 - cell.com
Although human core body temperature is known to decrease with age, the age
dependency of facial temperature and its potential to indicate aging rate or aging-related …

Programmed ageing: decline of stem cell renewal, immunosenescence, and Alzheimer's disease

R Lathe, D St. Clair - Biological Reviews, 2023 - Wiley Online Library
The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …

Using deep learning to predict abdominal age from liver and pancreas magnetic resonance images

A Le Goallec, S Diai, S Collin, JB Prost… - Nature …, 2022 - nature.com
With age, the prevalence of diseases such as fatty liver disease, cirrhosis, and type two
diabetes increases. Approaches to both predict abdominal age and identify risk factors for …

An integrative machine-learning meta-analysis of high-throughput omics data identifies age-specific hallmarks of Alzheimer's disease

MN Shokhirev, AA Johnson - Ageing Research Reviews, 2022 - Elsevier
Alzheimer's disease (AD) is an incredibly complex and presently incurable age-related brain
disorder. To better understand this debilitating disease, we collated and performed a meta …