Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …

Mechanical stress plays a critical role in cartilage development and homoeostasis.
Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs …

MicroRNAs (miRNAs) regulate several physiological and pathological processes involved in
various diseases, including osteoarthritis (OA). OA is the most common global …

Objectives Circular RNAs (circRNA) expression aberration has been identified in various
human diseases. In this study, we investigated whether circRNAs could act as competing …

MicroRNAs are small double-stranded RNAs, which negatively regulate gene expression
and have been shown to have key roles in both chondrocyte development and cartilage …

Background Osteoarthritis (OA), a disease with whole-joint damage and dysfunction, is the
leading cause of disability worldwide. The progressive loss of hyaline cartilage extracellular …

Osteoarthritis (OA) is the most common degenerative joint disease in the world. Gene
therapy based on delivering microRNAs (miRNAs) into cells has potential for the treatment …

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

Abstract Purpose of Review Osteoarthritis (OA) is a subset of joint disorders resulting in
degeneration of synovial joints. This leads to pain, disability and loss of independence …

Although osteoarthritis (OA) aetiology is complex, genetic, genomic and epigenetic studies
published within the last decade have advanced our understanding of the molecular …