Determining the migratory and invasive capacity of tumor and stromal cells and clarifying the
underlying mechanisms is most relevant for novel strategies in cancer diagnosis, prognosis …

Venous leg ulcers account for approximately 70% of all leg ulcers and affect 2.2 million
Americans annually. After a comprehensive patient and wound assessment, compression …

Brain postnatal development is characterized by critical periods of experience-dependent
remodeling of neuronal circuits. Failure to end these periods results in neurodevelopmental …

Tissue repair models are essential to explore the pathogenesis of wound healing and scar
formation, identify new drug targets/biomarkers and to test new therapeutics. However, no …

The gap junction protein, connexin43 (Cx43), has critical roles in the inflammatory,
edematous, and fibrotic processes following dermal injury and during wound healing, and is …

The most ubiquitous gap junction protein within the body, connexin 43 (Cx43), is a target of
interest for modulating the dermal wound healing response. Observational studies found …

Simple Summary The gap junction protein connexin 43 (Cx43) facilitates direct intercellular
communication and displays a complex dichotomous role in cancer. Here, we used breast …

In the epidermis, remodelling of Connexin43 is a key event in wound closure. However,
controversy between the role of connexin channel and non-channel functions exist. We …

Metastatic spread is the single‐most powerful predictor of poor outcome in Ewing sarcoma
(ES). Therefore targeting pathways that drive metastasis has tremendous potential to reduce …

Background Regulated alteration of connexin expression has been shown to be integral to
acute wound repair. Downregulation of the gap‐junction protein connexin 43 at the wound …