RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …

In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been …

Ras proteins play a direct causal role in human cancer with activating mutations in Ras
occurring in∼ 30% of tumours. Ras effectors also contribute to cancer, as mutations occur in …

Tumour suppressor gene inactivation is critical to the pathogenesis of cancers; such loss of
function may be mediated by irreversible processes such as gene deletion or mutation …

Summary p53 is regulated by multiple posttranslational modifications, including Hdm2-
mediated ubiquitylation that drives its proteasomal degradation. Here, we identify the p53 …

Loss of heterozygosity of the small arm of chromosome 3 is one of the most common
alterations in human cancer. Most notably, a segment in 3p21. 3 is frequently lost in lung …

Abstract Mammalian sterile 20–like kinase 1 (Mst1) is activated by both caspase-mediated
cleavage and phosphorylation in response to apoptotic stimuli, including Fas ligation. Here …

Abstract Deletions of the 3p21. 3 region are a frequent and early event in the formation of
lung, breast, kidney and other cancers. Intense investigation of allelic losses and the …

Genetic changes through allelic loss and nucleic acid or protein modifications are the main
contributors to loss of function of tumor suppressor proteins. In particular, epigenetic …

Cancer cells undergo many different alterations during their transformation, including
genetic and epigenetic events. The controlled division of healthy cells can be impaired …