Highlights•Senescent cells contribute to aging and age-related diseases.•Reducing the
secretory phenotype of senescent cells (SASP) has beneficial effects.•Elimination of …

Glucocorticoids serve as key stress response hormones that facilitate stress coping.
However, sustained glucocorticoid exposure is associated with adverse consequences on …

Cellular senescence suppresses cancer by arresting the proliferation of cells at risk for
malignant transformation. Recently, senescent cells were shown to secrete numerous …

CREB-mediated transcription can be initiated by membrane receptor stimulation and
subsequent activation of intracellular pathways to the cell nucleus, and has been described …

Amino acids such as leucine and its metabolite α-ketoisocaproate (KIC), are returning to be
the focus of studies, mainly because of their anti-catabolic properties, through inhibition of …

The steroid hormone receptors (SHRs) are ligand-dependent intracellular transcription
factors that are known to influence the development and growth of many human cancers …

Abstract β-Hydroxy-β-methylbutyrate (HMβ) supplementation is used to treat cancer, sepsis
and exercise-induced muscle damage. However, its effects on animal and human health …

Glucocorticoids exert rapid nongenomic effects by several mechanisms including the
activation of a membrane-bound glucocorticoid receptor (mGR). Here, we report the first …

Abstract Introduction Cytokines (IL-6, IL-10 and TNF-α) are increased after exhaustive
exercise in the rat retroperitoneal (RPAT) and mesenteric adipose tissue (MEAT) pads. On …

Adrenal hormones likely affect anti-predator behavior in animals. With experimental field
studies, we first investigated associations between mean fecal glucocorticoid metabolite …