Microbial resistance to antibiotics and effective antibiotherapy

AA Chiș, LL Rus, C Morgovan, AM Arseniu, A Frum… - Biomedicines, 2022 - mdpi.com
Currently, the efficacy of antibiotics is severely affected by the emergence of the
antimicrobial resistance phenomenon, leading to increased morbidity and mortality …

[HTML][HTML] Glucarpidase (carboxypeptidase G2): Biotechnological production, clinical application as a methotrexate antidote, and placement in targeted cancer therapy

F Moradbeygi, Y Ghasemi, AR Farmani… - Biomedicine & …, 2023 - Elsevier
Patients receiving high-dose methotrexate (HDMTX) for malignancies are exposed to
diverse complications, including nephrotoxicity, hepatotoxicity, mucositis, myelotoxicity …

Fabrication of zein-based hydrophilic nanoparticles for efficient gene delivery by layer-by-layer assembly

Y Chen, C Liu, Z Yang, Y Sun, X Chen, L Liu - International Journal of …, 2022 - Elsevier
As a natural biological macromolecule, zein has broad application prospects in drug
delivery due to its unique self-assembly properties. In this work, zein/sodium alginate …

Dendrimers: advancements and potential applications in cancer diagnosis and treatment—an overview

A Crintea, AC Motofelea, AS Șovrea, AM Constantin… - Pharmaceutics, 2023 - mdpi.com
Cancer is a leading cause of death worldwide, and the main treatment methods for this
condition are surgery, chemotherapy, and radiotherapy. These treatment methods are …

Biopolymeric prodrug systems as potential antineoplastic therapy

AA Chis, AM Arseniu, C Morgovan, CM Dobrea, A Frum… - Pharmaceutics, 2022 - mdpi.com
Nowadays, cancer represents a major public health issue, a substantial economic issue,
and a burden for society. Limited by numerous disadvantages, conventional chemotherapy …

Prodrugs: Harnessing chemical modifications for improved therapeutics

R Kumar, C Kaur, K Kaur, N Khurana… - Journal of Drug Delivery …, 2023 - Elsevier
A drug is a chemical substance which possesses medicinal properties and exerts
pharmacological action upon administration into the body. When a drug gets metabolized …

[PDF][PDF] S, ovrea, AS; Constantin, A

A Crintea, AC Motofelea - cancer, 2023 - academia.edu
Cancer is a leading cause of death worldwide, and the main treatment methods for this
condition are surgery, chemotherapy, and radiotherapy. These treatment methods are …

Antibody–Drug Conjugates—Evolution and Perspectives

AA Chis, CM Dobrea, AM Arseniu, A Frum… - International Journal of …, 2024 - mdpi.com
Antineoplastic therapy is one of the main research themes of this century. Modern
approaches have been implemented to target and heighten the effect of cytostatic drugs on …

Safety Profile of the Trastuzumab-Based ADCs: Analysis of Real-World Data Registered in EudraVigilance

C Morgovan, CM Dobrea, A Butuca, AM Arseniu… - Biomedicines, 2024 - mdpi.com
Trastuzumab (T) and tyrosine kinase inhibitors (TKIs) are among the first-line treatments
recommended for HER2-positive breast cancer. More recently, antibody-drug conjugates …

[PDF][PDF] 可电离脂质及其对载核酸药物脂质纳米粒转染效率和安全性的影响研究进展# br

何凤阳, 刘媛媛, 孟庆斌, 刘许歌… - 中国药理学与毒理学 …, 2024 - cjpt.magtechjournal.com
可电离脂质构成的脂质纳米粒(LNP) 是目前临床上最具应用前景的非病毒核酸药物递送载体之
一, 在递送基因治疗药物和疫苗等方面具有巨大潜力. LNP 的主要成分可电离脂质对LNP …