BACKGROUND A gap exists between in vivo and ex vivo coagulation when investigated by
use of the coagulation tests prothrombin time (PT) and activated partial thromboplastin time …

Venous thromboembolism (VTE) encompasses deep-vein thrombosis (DVT) and pulmonary
embolism. VTE is the leading cause of lost disability-adjusted life years and the third leading …

Background & Aims Non-alcoholic fatty liver disease (NAFLD) is characterized by increased
risk of cardiovascular events and liver-fibrosis. Both could be explained by a procoagulant …

Thrombin is the central enzyme in the coagulation cascade. Estimation of an individual's
potential to generate thrombin may correlate more closely with a hyper‐or hypo‐coagulable …

The recent development of semi-automated methods has revived interest in the thrombin
generation test, a global assay that measures the overall tendency of a plasma sample to …

Thrombin is a pivotal player in the coagulation system. In clotting blood a transient wave of
thrombin appears after a lag time. Clotting occurs at the start of the wave. The amount of …

Background: Thrombin generation is a powerful tool to probe overall plasma coagulability.
Objective: To determine which plasma factors influence the various parameters of the …

Abstract Adeno-associated virus (AAV)-based gene therapies can restore endogenous
factor VIII (FVIII) expression in hemophilia A (HA). AAV vectors typically use a B-domain …

Fibrinogen contributes to thrombosis risk in different ways. Indeed, various mutations in the
fibrinogen genes predispose to thrombosis. At the same time, high levels of fibrinogen are …

Objective To compare the impact on thrombin generation of the new combined oral
contraceptive containing 15 mg estetrol and 3 mg drospirenone with ethinylestradiol (30 or …