Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

Mammalian development requires effective mechanisms to repress genes whose
expression would generate inappropriately specified cells. The Polycomb-repressive …

Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

BACKGROUND Multicellular organisms depend on the precise orchestration of gene
expression to direct embryonic development and to maintain tissue homeostasis through …

Cancer biology is profoundly influenced by changes in the epigenome. Because the
dynamic plasticity of the epigenome lends itself well to therapeutic manipulation, the past …

Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles
in stem-cell identity, differentiation and disease. Mechanistically, they function within …

Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent
misexpression during differentiation and development. Some PcG proteins covalently modify …