CYP1A inhibitors: Recent progress, current challenges, and future perspectives

Z Dai, Y Wu, Y Xiong, J Wu, M Wang… - Medicinal Research …, 2024 - Wiley Online Library
Abstract Mammalian cytochrome P450 1A (CYP1A) are key phase I xenobiotic‐metabolizing
enzymes that play a distinctive role in metabolic activation or metabolic clearance of a …

Therapeutic targeting of p90 ribosomal S6 kinase

EB Wright, DA Lannigan - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
The Serine/Threonine protein kinase family, p90 ribosomal S6 kinases (RSK) are
downstream effectors of extracellular signal regulated kinase 1/2 (ERK1/2) and are activated …

Phytochemical components and GC–MS analysis of Petiveria alliaceae L. fractions and volatile oils

EO Adesanya, OO Oyesiku, OO Adesanya… - Physical Sciences …, 2024 - degruyter.com
Phytochemical constituents are important in the determination of plant activities. Their
presence in medicinal plants gives their therapeutic values. These phytoconstituents …

Exploring the Therapeutic Potential of Petiveria alliacea L. Phytochemicals: A Computational Study on Inhibiting SARS-CoV-2's Main Protease (Mpro)

MA Ali, H Sheikh, M Yaseen, MO Faruqe, I Ullah… - Molecules, 2024 - mdpi.com
The outbreak of SARS-CoV-2, also known as the COVID-19 pandemic, is still a critical risk
factor for both human life and the global economy. Although, several promising therapies …

Doxorubicin Activity Is Modulated by Traditional Herbal Extracts in a 2D and 3D Multicellular Sphere Model of Leukemia

L Corzo Prada, C Urueña, E Leal-García, A Barreto… - Pharmaceutics, 2023 - mdpi.com
The modulation of the tumor microenvironment by natural products may play a significant
role in the response of tumor cells to chemotherapy. In this study, we evaluated the effect of …

Inhibition of Human CYP1A1/A2 by a Hydroalcoholic Extract and Its Neolignan Constituents from Piperrivinoides

CH Ramos, R de Oliveira Santos, AM Marques… - Revista Brasileira de …, 2024 - Springer
Lignans and neolignans, commonly found in plants, are generally composed of two
phenylpropane (C6-C3) units with a marked diversity of molecular structures and biological …

Dibenzyl trisulfide induces caspase-independent death and lysosomal membrane permeabilization of triple-negative breast cancer cells

J Wooten, N Mavingire, CA Araújo, J Aja, S Wauchope… - Fitoterapia, 2022 - Elsevier
Abstract The Petiveria alliacea L.(P. alliacea) plant is traditionally used in folklore medicine
throughout tropical regions of the world to treat arthritis, asthma, and cancer. Dibenzyl …

In Silico Design and SAR Study of Dibenzyl Trisulfide Analogues for Improved CYP1A1 Inhibition

N Clarke, W Irvine - ChemistryOpen, 2022 - Wiley Online Library
Dibenzyl trisulfide (DTS) is a natural compound with potential cancer‐preventive properties
occurring in Petiveria alliacea L., an ethnomedicinal plant native to the Americas. Previous …

[PDF][PDF] Evaluation of cryopreservation of Petiveria alliacea somatic embryos based on stress caused for the method used Avaliação da criopreservação de embriões …

A da Silva Gonçalves… - Brazilian Journal of …, 2021 - researchgate.net
Petiveria alliacea é uma espécie medicinal com grande potencial de uso farmacológico
contra diversas patologias, incluindo neoplasias. Muitos estudos têm sido desenvolvidos …