The choice of biomaterials available for regenerative medicine continues to grow rapidly,
with new materials often claiming advantages over the short-comings of those already in …

Background: There has been a surge in high-level studies investigating platelet-rich plasma
(PRP) for tendon and ligament injuries. A number of meta-analyses have been published …

Tendon is a specific connective tissue composed of parallel collagen fibers. The effect of this
tissue-specific matrix orientation on stem cell differentiation has not been investigated. This …

An ideal scaffold that provides a combination of suitable mechanical properties along with
biological signals is required for successful ligament/tendon regeneration in mesenchymal …

Tissue engineering scaffolds should ideally mimic the natural ECM in structure and function.
Electrospun nanofibrous scaffolds are easily fabricated and possess a biomimetic …

While a wide variety of approaches to engineering orthopedic tissues have been proposed,
less attention has been paid to the interfaces, the specialized areas that connect two tissues …

A mesenchymal stem cell (MSC)-seeded collagen gel under static or dynamic tension is a
well-established model to study the potential of MSCs in regenerating a tendon-or ligament …

Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery.
The ideal treatment for such tissue loss is autografting, but donor sites are often limited …

Tendon ruptures are increasingly common, repair can be difficult, and healing is poorly
understood. Tissue engineering approaches often require expansion of cell numbers to …

This study was aimed to develop a new practical ligament scaffold by synergistic
incorporation of silk fibers, a knitted structure, and a collagen matrix. The efficacy for …