Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …

Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15
months despite an aggressive standard of care that includes surgery, chemotherapy, and …

Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma
cells forms a functional and therapy-resistant tumor cell network interconnected by tumor …

The mainstay of treatment for adult patients with gliomas, glioneuronal and neuronal tumors
consists of combinations of surgery, radiotherapy, and chemotherapy. For many systemic …

Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

The most frequently mutated metabolic genes in human cancer are those encoding the
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …

Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For
Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall …

Background Patient-derived glioma stem-like cells (GSCs) have become the gold-standard
in neuro-oncological research; however, it remains to be established whether loss of in situ …

Brain cancer remains the deadliest cancer. The blood–brain barrier (BBB) is impenetrable to
most drugs and is a complex 3D network of multiple cell types including endothelial cells …

Neural–tumor interactions drive glioma growth as evidenced in preclinical models, but
clinical validation is limited. We present an epigenetically defined neural signature of …