Neuronal implementation of the temporal difference learning algorithm in the midbrain dopaminergic system

A Stetsenko, T Koos - … of the National Academy of Sciences, 2023 - National Acad Sciences
The temporal difference learning (TDL) algorithm has been essential to conceptualizing the
role of dopamine in reinforcement learning (RL). Despite its theoretical importance, it …

Sex mechanisms as nonbinary influences on cognitive diversity

NM Grissom, N Glewwe, C Chen, E Giglio - Hormones and Behavior, 2024 - Elsevier
Essentially all neuropsychiatric diagnoses show some degree of sex and/or gender
differences in their etiology, diagnosis, or prognosis. As a result, the roles of sex-related …

Cross‐species translational paradigms for assessing positive valence system as defined by the RDoC matrix

TD Dexter, BZ Roberts, SM Ayoub… - Journal of …, 2024 - Wiley Online Library
Functions associated with processing reward‐related information are fundamental drivers of
motivation, learning, and goal‐directed behavior. Such functions have been classified as the …

Methamphetamine increases risky choice in rats, but only when magnitude and probability of reinforcement are manipulated within a session

JR Yates, S Adhikari, RE Bako, KL Berling… - Pharmacology …, 2024 - Elsevier
Risky choice is associated with maladaptive behaviors, particularly substance use disorders.
Current animal models of risky choice are often confounded by other constructs like …

Differential processing of delay versus uncertainty in male but not female 16p11. 2 hemideletion mice

GR Rojas, AT Heller, NM Grissom - bioRxiv, 2023 - biorxiv.org
Neurodevelopmental disorders are associated with differences in learning and motivation
that can influence executive function, including behavioral flexibility and decision making …

Effects of delay sequence in a delay discounting task

JR Macías-Navarrete, CV Dos Santos - Behavioural Processes, 2024 - Elsevier
Delay discounting refers to the decrease in subjective value of a reward as the delay until its
receipt increases. In the present study we assessed the effects of the sequence of delay …

From alleles to adaptations: Investigating the genetic landscape of C. elegans in response to ethanol

MH van Wijk - 2024 - search.proquest.com
Alcohol use disorder (AUD) is a worldwide problem and the risk of developing this disease
is partly genetically regulated. Ethanol responses are conserved among mammals and …

Development and employment of discounting tasks in 16p11. 2 hemideletion mice

GR Rojas - 2023 - search.proquest.com
Humans must wait or make risky decisions to obtain different commodities of varying value.
These decisions rely on learning the value of those commodities and adapting choices to …