Assessing spatial learning and memory in rodents

CV Vorhees, MT Williams - ILAR journal, 2014 - academic.oup.com
Maneuvering safely through the environment is central to survival of almost all species. The
ability to do this depends on learning and remembering locations. This capacity is encoded …

Assessment of spatial memory in mice

S Sharma, S Rakoczy, H Brown-Borg - Life sciences, 2010 - Elsevier
Improvements in health care have greatly increased life span in the United States. The focus
is now shifting from physical well-being to improvement in mental well-being or maintenance …

Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains

SS Moy, JJ Nadler, NB Young, A Perez… - Behavioural brain …, 2007 - Elsevier
Three defining clinical symptoms of autism are aberrant reciprocal social interactions,
deficits in social communication, and repetitive behaviors, including motor stereotypies and …

A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer's disease mouse model

N Ortí-Casañ, IS Zuhorn, PJW Naudé… - Proceedings of the …, 2022 - National Acad Sciences
Tumor necrosis factor-α (TNF-α) is a pleiotropic, proinflammatory cytokine related to different
neurodegenerative diseases, including Alzheimer's disease (AD). Although the linkage …

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

JW Young, SB Powell, V Risbrough, HM Marston… - Pharmacology & …, 2009 - Elsevier
Cognitive deficits in schizophrenia are among the core symptoms of the disease, correlate
with functional outcome, and are not well treated with current antipsychotic therapies. In …

Spatial memory: Theoretical basis and comparative review on experimental methods in rodents

CM Paul, G Magda, S Abel - Behavioural brain research, 2009 - Elsevier
The assessment of learning and memory in animal models has been widely employed in
scientific research for a long time. Among these models, those representing diseases with …

Chronic cellular imaging of mouse visual cortex during operant behavior and passive viewing

ML Andermann, AM Kerlin, C Reid - Frontiers in cellular …, 2010 - frontiersin.org
Nearby neurons in mammalian neocortex demonstrate a great diversity of cell types and
connectivity patterns. The importance of this diversity for computation is not understood …

Drug discovery in dementia: the role of rodent models

D Van Dam, PP De Deyn - Nature reviews Drug discovery, 2006 - nature.com
Recent advances in the understanding of the pathophysiological mechanisms underlying
Alzheimer's disease have pointed to novel strategies for drug development. Animal models …

A review of behavioral methods for the evaluation of cognitive performance in animal models: current techniques and links to human cognition

M Ghafarimoghadam, R Mashayekh, M Gholami… - Physiology & …, 2022 - Elsevier
Introduction: Memory is defined as the ability to store, maintain and retrieve information.
Learning is the acquisition of information that changes behavior and memory. Stress …

Sex differences in cognition across aging

BH Lee, JE Richard, RG de Leon, S Yagi… - Sex differences in brain …, 2022 - Springer
Sex and gender differences are seen in cognitive disturbances in a variety of neurological
and psychiatry diseases. Men are more likely to have cognitive symptoms in schizophrenia …