Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …

Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

The immune system is a fascinating world of cells, soluble factors, interacting cells, and
tissues, all of which are interconnected. The highly complex nature of the immune system …

Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

Background Asthma is a common condition due to chronic inflammation of the lower
respiratory tract. Chronic lower airway inflammation is known to be more common in …

Background Bronchial asthma is one of the most common chronic diseases in childhood,
with a current prevalence of 6% to 9%, but a prevalence that is increasing at an alarming …

Asthma is a common disorder that in 2009 afflicted 8.2% of adults and children, 24.6 million
persons, in the United States. In patients with moderate and severe persistent asthma, there …

Allergies are complex diseases that result from interactions between multiple genetic and
environmental factors. However, the increase in allergies observed in the past decades is …

IgE-dependent mast cell activation is a major effector mechanism underlying the pathology
associated with allergic disorders. The most dramatic of these IgE-associated disorders is …

BACKGROUND: Atopic dermatitis (AD) is a common skin disease that is characterized by
recurrent episodes of itching. Filaggrin (FLG) loss-of-function (FLG null) mutations have …