Poxviruses are large, enveloped viruses that replicate in the cytoplasm and encode proteins
for DNA replication and gene expression. Hairpin ends link the two strands of the linear …

Virus replication can cause extensive rearrangement of host cell cytoskeletal and membrane
compartments leading to the “cytopathic effect” that has been the hallmark of virus infection …

The family Poxviridae contains two subfamilies: the Entomopoxvirinae (poxviruses of
insects) and the Chordopoxvirinae (poxviruses of vertebrates). Here we present the first …

Phosphorylation represents one the most abundant and important posttranslational
modifications of proteins, including viral proteins. Virus-encoded serine/threonine protein …

Mitotic chromatin condensation is essential for cell division in eukaryotes. Posttranslational
modification of the N-terminal tail of histone proteins, particularly by phosphorylation by …

Even if a virus successfully binds to a cell, defects in any of the downstream steps of the viral
life cycle can preclude the production of infectious virus particles. Such abortive infections …

Early events play a decisive role in virus multiplication. We have shown previously that
activation of MAPK/ERK1/2 (mitogen-activated protein kinase/extracellular-signal-regulated …

The tumour suppressor p53 protein integrates multiple signals regulating cell cycle
progression and apoptosis. This regulation is mediated by several kinases that …

The Barrier to Autointegration Factor (BAF or BANF1) is an abundant, highly conserved DNA
binding protein. BAF is involved in multiple pathways including mitosis, nuclear assembly …

A cDNA library enriched for human fetal-specific liver genes was constructed by suppressive
subtractive hybridization. EST fls223 generated from this library was found to represent a …