Prion diseases are infectious neurodegenerative diseases occurring in humans and animals
with an invariably lethal outcome. One fundamental mechanistic event in prion diseases is …

Atypical/Nor98 scrapie cases in sheep were diagnosed for the first time in Norway in 1998.
They are now identified in small ruminants in most European countries and represent an …

Prion diseases are fatal, transmissible neurodegenerative disorders associated with
conversion of the host‐encoded prion protein (PrPC) into an abnormal pathogenic isoform …

Objective To report a novel prion disease characterized by distinct histopathological and
immunostaining features, and associated with an abnormal isoform of the prion protein (PrP) …

Prions are unconventional infectious agents thought to be primarily composed of PrPSc, a
multimeric misfolded conformer of the ubiquitously expressed host-encoded prion protein …

Prions arise when the cellular prion protein (PrPC) undergoes a self-propagating
conformational change; the resulting infectious conformer is designated PrPSc. Frequently …

Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) or prion
disease of sheep and goats. Scrapie is a protein misfolding disease where the normal prion …

Isolates of atypical scrapie recently identified in sheep and goats in France were compared
with Nor98 isolates reported in Norway. Western blot methods for characterization of the …

Prion diseases affect a wide range of mammal species and are caused by a misfolded self-
propagating isoform (PrPSc) of the normal prion protein (PrPC). Distinct strains of prions …

Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disease that belongs
to a group of diseases known as transmissible spongiform encephalopathies (TSEs). It is …