Behaviours of complex biomolecular systems are often irreducible to the elementary
properties of their individual components. Explanatory and predictive mathematical models …

The key signalling pathways and transcriptional programmes that instruct neuronal diversity
during development have largely been identified. In this Review, we discuss how this …

Humans differ from other animals in many aspects of anatomy, physiology, and behaviour;
however, the genotypic basis of most human-specific traits remains unknown. Recent whole …

Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal
differentiation when expressed in neural progenitor cells. The mechanisms by which …

The human cerebral cortex depends for its normal development and size on a precisely
controlled balance between self-renewal and differentiation of diverse neural progenitor …

Neural stem cell self-renewal, neurogenesis, and cell fate determination are processes that
control the generation of specific classes of neurons at the correct place and time. The …

The developing cerebral cortex contains apical and basal types of neurogenic progenitor
cells. Here, we investigated the cellular properties and neurogenic output of basal …

Advances in cellular reprogramming and stem cell differentiation now enable ex vivo studies
of human neuronal differentiation. However, it remains challenging to elucidate the …

Survival and integration of new neurons in the hippocampal circuit are rate-limiting steps in
adult hippocampal neurogenesis. Neuronal network activity is a major regulator of these …

Direct lineage reprogramming induces dramatic shifts in cellular identity, employing poorly
understood mechanisms. Recently, we demonstrated that expression of Neurog2 or Ascl1 in …