Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Cancer is one of the leading causes of death worldwide, accounting for nearly 10 million
deaths in 2020. Therefore, cancer therapy is a priority research field to explore the biology of …

The high frequency of breast cancer worldwide and the high mortality among women with
this malignancy are a serious challenge for modern medicine. A deeper understanding of …

p53 is a transcription factor that activates the expression of a set of genes that serve as a
critical barrier to oncogenesis. Inactivation of p53 is the most common characteristic in …

A class of chaperones dubbed heat shock protein 70 (Hsp70) possesses high relevance in
cancer diseases due to its cooperative activity with the well-established anticancer target …

The pro-oncogenic activities of estrogen receptor alpha (ERα) drive breast cancer
pathogenesis. Endocrine therapies that impair the production of estrogen or the action of the …

Luminal A breast cancer, constituting 70% of breast cancer cases, presents a challenge due
to the development of resistance and recurrence caused by breast cancer stem cells …

Simple Summary Mortalin is a heat shock protein 70 stress chaperone family member with
variable subcellular localization in normal and cancer cells. It is an essential protein with …

Simple Summary The Hsp70 family stress chaperone mortalin plays an important role in
carcinogenesis and hence has emerged as a candidate target for cancer drug development …

Mortalin, a heat shock family protein enriched in cancer cells, is known to inactivate tumor
suppressor protein p53. Abrogation of mortalin-p53 interaction and reactivation of p53 has …