Abstract The Replication Protein A (RPA) complex is an essential regulator of eukaryotic
DNA metabolism. RPA avidly binds to single-stranded DNA (ssDNA) through multiple …

Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …

Replication protein A [RPA; also known as replication factor A (RFA) and human single-
stranded DNA-binding protein] is a single-stranded DNA-binding protein that is required for …

Epidemiological evidence indicates that avoidance of smoking, increased consumption of
fruits and vegetables, and control of infections will have a major effect on reducing rates of …

As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of
the critical and complex roles played by p53 is progressing rapidly, new findings continue to …

Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …

Functional inactivation of p53 by gene mutation and deletion, protein degradation, or viral
oncogene binding renders a mammalian cell susceptible to oncogenic stimuli and …

Abnormalities of the p53 tumour suppressor gene are among the most frequent molecular
events in human and animal neoplasia. Moreover, p53 is one of the most studied proteins in …

The crucial differences between normal cells and cancer cells stem from discrete changes in
specific genes controlling proliferation and tissue homeostasis. Over 100 such cancer …

Saccharomyces cells suffering a single unrepairable double-strand break (DSB) exhibit a
long, but transient arrest at G2/M. hdf1 cells, lacking Ku70p, fail to escape from this …