Tuberous sclerosis complex is a rare genetic disease associated with mutations in the TSC1
or TSC2 genes, which cause overactivation of the mTOR complex. In the past 5 years …

Patients with tuberous sclerosis complex (TSC) are at very high risk for developing epilepsy,
and the majority experience seizure onset during the first year of life. Early targeted …

Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease
affecting multiple body systems with wide variability in presentation. In 2013, Pediatric …

Importance Efficacy of cannabidiol has been demonstrated in seizures associated with
Lennox-Gastaut and Dravet syndromes but appears not yet to have been established in …

Objective To present the baseline data of the international TuberOus SC lerosis registry to
increase disease Awareness (TOSCA) with emphasis on the characteristics of epilepsies …

Objective To evaluate the long‐term safety and efficacy of add‐on cannabidiol (CBD) in
patients with seizures associated with tuberous sclerosis complex (TSC) in the open‐label …

Background Most evidence for TSC-associated neuropsychiatric disorders (TAND) to date
have come from small studies and case reports, and very little is known about TAND in …

Abstract Background Tuberous Sclerosis Complex (TSC) is a rare multisystem disorder. In
2012 diagnostic criteria for TSC were revised. However, data on the incidence of TSC are …

Objective This review will summarize current knowledge on the burden of illness (BOI) in
tuberous sclerosis complex (TSC), a multisystem genetic disorder manifesting with …

Tuberous sclerosis complex (TSC) involves abnormalities of the skin (hypomelanotic
macules, confetti skin lesions, facial angiofibromas, shagreen patches, fibrous cephalic …