Inflammation, vitamin B6 and related pathways
PM Ueland, A McCann, Ø Midttun, A Ulvik - Molecular aspects of medicine, 2017 - Elsevier
The active form of vitamin B6, pyridoxal 5′-phosphate (PLP), serves as a co-factor in more
than 150 enzymatic reactions. Plasma PLP has consistently been shown to be low in …
than 150 enzymatic reactions. Plasma PLP has consistently been shown to be low in …
[HTML][HTML] Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation
CA Labarrere, GS Kassab - Frontiers in Nutrition, 2022 - frontiersin.org
Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome
Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has
reached epidemic proportions with no pharmacological therapy approved. Lower circulating …
reached epidemic proportions with no pharmacological therapy approved. Lower circulating …
A metabolomic profile of biological aging in 250,341 individuals from the UK Biobank
The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic
resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 …
resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 …
Exome sequencing of Finnish isolates enhances rare-variant association power
Exome-sequencing studies have generally been underpowered to identify deleterious
alleles with a large effect on complex traits as such alleles are mostly rare. Because the …
alleles with a large effect on complex traits as such alleles are mostly rare. Because the …
Insulin resistance and glycine metabolism in humans
M Adeva-Andany, G Souto-Adeva… - Amino Acids, 2018 - Springer
Plasma glycine level is low in patients with obesity or diabetes and the improvement of
insulin resistance increases plasma glycine concentration. In prospective studies …
insulin resistance increases plasma glycine concentration. In prospective studies …
[HTML][HTML] Glycine and aging: Evidence and mechanisms
AA Johnson, TL Cuellar - Ageing research reviews, 2023 - Elsevier
The restriction of calories, branched-chain amino acids, and methionine have all been
shown to extend lifespan in model organisms. Recently, glycine was found to boost …
shown to extend lifespan in model organisms. Recently, glycine was found to boost …
Assessing the causal association of glycine with risk of cardio-metabolic diseases
LBL Wittemans, LA Lotta, C Oliver-Williams… - Nature …, 2019 - nature.com
Circulating levels of glycine have previously been associated with lower incidence of
coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine …
coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine …
Bifidobacterium lactis Probio-M8 adjuvant treatment confers added benefits to patients with coronary artery disease via target modulation of the gut-heart/-brain axes
Accumulating evidence suggests that gut dysbiosis may play a role in cardiovascular
problems like coronary artery disease (CAD). Thus, target steering the gut microbiota …
problems like coronary artery disease (CAD). Thus, target steering the gut microbiota …
Muscle-liver trafficking of BCAA-derived nitrogen underlies obesity-related glycine depletion
Glycine levels are inversely associated with branched-chain amino acids (BCAAs) and
cardiometabolic disease phenotypes, but biochemical mechanisms that explain these …
cardiometabolic disease phenotypes, but biochemical mechanisms that explain these …