A major shift in our understanding of genome regulation has emerged recently. It is now
apparent that the majority of cellular transcripts do not code for proteins, and many of them …

Networks of regulatory enhancers dictate distinct cell identities and cellular responses to
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …

A crucial feature of differentiated cells is the rapid activation of enhancer-driven
transcriptional programs in response to signals. The potential contributions of …

Enhancers are cis-regulatory elements in the genome that cooperate with promoters to
control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent …

CBP/p300 are transcription co-activators whose binding is a signature of enhancers, cis-
regulatory elements that control patterns of gene expression in multicellular organisms …

The enhancer regions of the myogenic master regulator MyoD give rise to at least two
enhancer RNAs. Core enhancer eRNA (CE eRNA) regulates transcription of the adjacent …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Metazoan genomes are broadly transcribed by RNA polymerase II (RNAPII), but surprisingly
few of these RNAs encode proteins. Accordingly, there is great interest in understanding the …

Despite extensive progress in developing anticancer therapies, therapy resistance remains
a major challenge that promotes disease relapse. The changes that lead to therapy …

Enhancers are important cis‐acting elements that can regulate gene transcription and cell
fate alongside promoters. In fact, many human cancers and diseases are associated with the …