[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …
a significant degree of variation within populations. IgG glycome composition is influenced …
The history of IgG glycosylation and where we are now
BA Cobb - Glycobiology, 2020 - academic.oup.com
IgG glycosylation is currently at the forefront of both immunology and glycobiology, likely due
in part to the widespread and growing use of antibodies as drugs. For over four decades, it …
in part to the widespread and growing use of antibodies as drugs. For over four decades, it …
Glycosylation profile of immunoglobulin G is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent …
Rationale: One measure of protein glycosylation (GlycA) has been reported to predict higher
cardiovascular risk by reflecting inflammatory pathways. Objective: The main objective of this …
cardiovascular risk by reflecting inflammatory pathways. Objective: The main objective of this …
N-glycans as functional effectors of genetic and epigenetic disease risk
N-glycosylation is a frequent modification of proteins, essential for all domains of life. N-
glycan biosynthesis is a dynamic, complex, non-templated process, wherein specific …
glycan biosynthesis is a dynamic, complex, non-templated process, wherein specific …
Immunoglobulin G glycans–Biomarkers and molecular effectors of aging
Immunoglobulin G (IgG) antibodies are post-translationally modified by the addition of
complex carbohydrate molecules–glycans, which have profound effects on the IgG function …
complex carbohydrate molecules–glycans, which have profound effects on the IgG function …
[HTML][HTML] Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up
I Gudelj, PP Salo, I Trbojević-Akmačić, M Albers… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Antibodies are known to have an important role in the development of rheumatoid arthritis
(RA), one of the most prevalent chronic inflammatory diseases which primarily involves the …
(RA), one of the most prevalent chronic inflammatory diseases which primarily involves the …
[HTML][HTML] N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease
Background Chronic obstructive pulmonary disease (COPD) is a complex condition, whose
diagnosis requires spirometric assessment. However, considering its heterogeneity …
diagnosis requires spirometric assessment. However, considering its heterogeneity …
[HTML][HTML] Heritability of the glycan clock of biological age
Immunoglobulin G is posttranslationally modified by the addition of complex N-glycans
affecting its function and mediating inflammation at multiple levels. IgG glycome composition …
affecting its function and mediating inflammation at multiple levels. IgG glycome composition …
Nanosponges: an overlooked promising strategy to combat SARS-CoV-2
Highlights•Nanosponges are explored for their antiviral delivery and biological
neutralization potentials.•Cellular nanosponges block interactions between SARS-CoV-2 …
neutralization potentials.•Cellular nanosponges block interactions between SARS-CoV-2 …
DNA methylation as a mediator of associations between the environment and chronic diseases: A scoping review on application of mediation analysis
ABSTRACT DNA methylation (DNAm) is one of the most studied epigenetic modifications.
DNAm has emerged as a key biological mechanism and biomarkers to test associations …
DNAm has emerged as a key biological mechanism and biomarkers to test associations …